Teenage Mutant Ninja Turtles: Out of the Shadows is a 2016 American superhero film based on the fictional superhero team the Teenage Mutant Ninja Turtles. It is the sixth film in the Teenage Mutant Ninja Turtles film series, the second and final film in the reboot series and a sequel to the 2014 film Teenage Mutant Ninja Turtles. The film was directed by Dave Green, written by Josh Appelbaum and André Nemec and stars Megan Fox, Stephen Amell, Will Arnett, Laura Linney, Brian Tee, Brittany Ishibashi and Tyler Perry and featuring the voices of Pete Ploszek, Alan Ritchson, Noel Fisher, Jeremy Howard, Tony Shalhoub, Gary Anthony Williams, Sheamus, and Brad Garrett.

Principal photography on the film began on April 27, 2015, in New York City. It was released on June 3, 2016, in 3D, RealD 3D, 4DX and in IMAX 3D. It received mixed reviews from critics, being considered by many an improvement over its predecessor, but was not as successful, grossing $245 million against a $135 million budget, resulting in a planned third film being scrapped. A reboot of the film series was later announced in 2018.